Autosomal recessive OSMRβ deficiency: Connecting OSM and/or IL-31 with atopy

Abstract

In this News & Views, we discuss two studies reporting autosomal recessive OSMRβ deficiency as a new inborn error of immunity marked by severe atopy, hyper-IgE, and eosinophilia, thereby refining the genetic dissection of STAT3-dependent hyper-IgE syndrome.