Preventive Cardiovascular Medication Prescribing Patterns in Menopausal Women

Abstract

Objective To characterize longitudinal prescribing patterns of preventive cardiovascular medications among women with nonsurgical menopause and women with surgical menopause to better identify potential differences in care. Patients and Methods We conducted a retrospective multicenter review using TriNetX from January 27, 2006, to January 27, 2026 (TriNetX analyzes up to 20 years of data before the analysis date). Nonsurgical and surgical menopause patients were compared regarding statin, antihypertensive, and diabetes medication prescription rates over 5 years. Prescribing patterns were additionally analyzed based on medication classes. Results A total of 690,799 nonsurgical menopause patients and 28,473 surgical menopause patients were queried. Nonsurgical menopausal women consistently had lower rates of statin (6.0%), antihypertensive (17.1%), and diabetes medications (7.7%) over 5 years than surgical menopause patients (P<.0001). Conclusion Surgical menopause patients had higher rates of statin, antihypertensive, and diabetes prescriptions than nonsurgical menopause patients matched by age and comorbidities. Providers should be cognizant of the interplay between menopause status and cardiovascular risk when prescribing preventive cardiovascular medications.