Application of non-invasive electroencephalogram-based brain-computer interfaces in post-stroke hand function rehabilitation.
TL;DR
The neurophysiological basis of EEG-BCI and three major rehabilitation paradigms are outlined, including motor imagery with physical feedback, motor imagery with virtual/multisensory feedback, and the steady-state visual evoked potential (SSVEP)-driven paradigm.
Abstract
Background
Post-stroke hand dysfunction severely limits patients' independence, and conventional rehabilitation often fails those without active movement. Noninvasive EEG-based brain-computer interface (BCI) technology addresses this by creating a closed-loop feedback system rooted in Hebbian learning principles. This system decodes rhythmic signals from the sensorimotor cortex during imagined hand movements in real-time. The decoded intention is then translated into commands to drive exoskeletons, functional electrical stimulation (FES), or virtual reality (VR) devices, thereby moving the affected limb. This process strengthens or remodels damaged neural pathways, promoting motor recovery.
Methods
This article systematically outlines the neurophysiological basis of EEG-BCI and three major rehabilitation paradigms: motor imagery with physical feedback, motor imagery with virtual/multisensory feedback, and the steady-state visual evoked potential (SSVEP)-driven paradigm.
Results
Studies confirm these approaches can improve upper limb function, showing significant potential. However, widespread clinical use faces challenges like low signal-to-noise ratios, significant individual variability, and "BCI blindness."
Conclusions
Future work should focus on improving decoding algorithms, developing more user-friendly devices, deepening mechanistic understanding, and establishing standardized clinical assessments. This review aims to offer valuable guidance for subsequent research.