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TL;DR
Exercise is associated with significant BDNF increases in neurological populations with MS and PD, particularly with longer sessions and combined training, and findings should be considered hypothesis-generating.
Circulating BDNF does not directly establish central BDNF engagement or enhanced neuroplasticity, and current review-level evidence does not establish a universal response, clinical benefit, superior modality, or optimal dose.
Background Global aging leads to increased age-related cognitive decline and neurodegenerative diseases like dementia. Brain-derived neurotrophic factor (BDNF) is crucial for neuronal survival, synaptic plasticity, and cognitive function, but its levels often decline with age. Physical exercise can potentially elevate...
Objective To systematically evaluate the effects of exercise interventions on brain-derived neurotrophic factor (BDNF) in patients with stroke, and to examine the dose–response relationships associated with acute and long-term exercise. Methods PubMed, Embase, Web of Science, the Cochrane Library, and APA PsycINFO were...
Current evidence suggests the PGC-1alpha–FNDC5–irisin–BDNF axis may constitute a molecular link between skeletal muscle activity and brain health; causal conclusions are limited by the associative and largely preclinical nature of the evidence.
The subgroup analysis indicated that the type of surgery may contribute to the high heterogeneity observed in 24-h postoperative BDNF and in 24-h postoperative ΔBDNF, and suggest that intraoperative BDNF levels and their dynamic changes may serve as preliminary exploratory biomarker for POCD.
The aim of this review was to examine if Brain-Derived Neurotrophic Factor (BDNF) could be a predictor for post-stroke depression (PSD). We searched Web of Science, Embase, PubMed, and Scopus databases for all relevant studies, with no language restrictions from inception of databases to 1st September 2025. We analyzed...
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