Aug 2026· Pediatric Research· 0 citations· 34 references
Medicine
TL;DR
A sex-specific protective effect of puberty on MASLD risk in children, with advancing puberty associated with significantly lower odds of MASLD in boys, but not in girls.
Adrenal androgen activity, reflected by DHEA-S, represents a significant endocrine pathway linking obesity to accelerated skeletal maturation, highlighting developmentally specific windows of endocrine-metabolic interaction in growing children.
Youngha Choi, Eunju Lee, H. Lee et al.· Frontiers in Endocrinology· 0 citations
Higher BMI in girls is associated with earlier onset of puberty and menarche, and girls with higher BMI reached pubertal milestones and menarche earlier than their normal-weight and underweight peers.
Maryam Esmaeili, M. R. Maracy, Roya Kelishadi et al.· BMJ Paediatrics Open· 0 citations
Early menarche is linked to increased depression risk, especially among women aged 18-30 years, especially among women aged 18-30 years, and may serve as a key point for early intervention to prevent depression in young women.
Qian-Nan Liu, Renke He, Yizhuo Miao et al.· Journal of Adolescent Health· 0 citations
A systematic review and meta-analysis supports a clinically relevant association between testosterone deficiency and MASLD, although evidence for the bidirectional nature of this relationship remains asymmetric but supports a clinically relevant endocrine-hepatic axis.
G. Spaggiari, L. Valentina, C. Felicani et al.· Andrology· 0 citations
Background CYP19A1 encodes aromatase, the enzyme converting androgens to estrogens, thereby influencing breast tissue development in healthy children. Objective To examine associations between CYP19A1 single nucleotide polymorphisms (SNPs) and circulating estradiol (E2) and testosterone (T), the E2/T ratio and age at t...
Veronica L R Groendahl, S. Holmboe, A. Busch et al.· Endocrine Connections· 0 citations
Childhood obesity is associated with significant hormonal and metabolic alterations, suggesting early endocrine adaptations that may have metabolic implications, and findings highlight need for early identification and intervention to prevent potential long-term cardiometabolic risks associated with pediatric-onset obe...
Rakhi Jain, P. Upadhyay· International Journal of Con...· 0 citations
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