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Current challenges in GWAS integration and fine-mapping for variant interpretation

Omar Y. Ahmed N. Saravanan A. B. Rovsing Danny Simpson Archit Devarajan Sophia Gunn T. Singh Tuuli Lappalainen Neville E. Sanjana
Jul 2026 · bioRxiv · 0 citations · 73 references
Medicine Biology

TL;DR

The current challenges for using GWAS to prioritize variants for functional follow-up experiments are described and a multi-modal approach for resolving GWAS loci to a focused set of high-confidence variants for functional exploration is suggested.

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