Improved MDD-recurrence understanding is aimed at by studying these four selected perspectives in combination and prospectively during remission by studying different predictors of recurrence in combination.
Major depressive disorder (MDD) has been associated with accelerated structural brain aging, yet whether this reflects a pre-existing neurobiological vulnerability, a dynamic acute state effect, or an accumulating biological residual remains unresolved. Across two longitudinal cohorts (N=3220), including a unique sampl...
M. Konowski, A. Kraus, J. Goltermann et al.· medRxiv· 0 citations
A multi-level perspective on the dynamic neural mechanisms of suicidality is provided and regional and network-level dynamic abnormalities may differentially contribute to trait SI, recent SI, and treatment-related improvements.
Yi-Fan Jing, Lin Jing, Xiong-Ying Chen et al.· Journal of Affective Disorde...· 0 citations
Gut microbiome provides a candidate approach for potential risk stratification in psychiatric populations, and MDD + RBD may represent a biologically distinct depression subtype associated with potential neurodegenerative risk.
Yuhua Yang, Ningning Li, Li Zhou et al.· Molecular Psychiatry· 0 citations
The neurobiological basis of cognitive impairment in MDD is explored, key biomarkers associated with these deficits are identified, and their implications for diagnosis, prognosis, and therapeutic intervention are discussed.
Akansha Thakur, Parag Jain, M. Sharma et al.· Current Behavioral Neuroscie...· 0 citations
The moderating effect of CR on the brain network-cognition association provides a neurobiological rationale for this vulnerability and supports incorporating CR into routine clinical assessment to guide risk stratification and personalized treatment planning.
M. Gruber, Henrike Renaud, M. Mauritz et al.· Psychotherapy and Psychosoma...· 0 citations
Mixed features were highly prevalent and associated with greater clinical burden, and Assessment of mixed features may provide clinically relevant information when selecting next-step pharmacologic strategies, particularly when considering a switch to bupropion sustained release.
Sidney Zisook, Lori L Davis, Trisha Suppes et al.· Journal of Psychopharmacolog...· 0 citations
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