Review

Residual Cholesterol Inflammatory Index: A Predictor of Cardiovascular-Kidney-Metabolic Syndrome; Insights from NHANES and CHARLS Cohorts.

Mengchen Zhang Linlin Huang Tian Zhang Guobin Song Xiaobin Ren Lijuan Zhang Aiyun Han

Jul 2026 · Anatolian journal of cardiology · 0 citations

Medicine

TL;DR

RCII exhibited an independent and positive association with CKM risk in the US and Chinese populations, with consistent dose-response and nonlinear trends, and may be a practical and integrative biomarker for identifying individuals with an increased CKM risk.

DOI PubMed Semantic Scholar

View source

Similar papers

Review Aug 2026

Associations Between the Inflammation Burden Index and Cardiovascular–Kidney–Metabolic Syndrome: A Cross-Sectional Study Based upon the NHANES Database

Elevated IBI holds promise for identifying individuals at high risk for advanced CKM syndrome as a composite inflammatory index that integrates multiple inflammatory cells and acute-phase proteins.

Yi-Xuan Wu, Mei Li, Zhen Fang et al. · Metabolic Syndrome and Relat... · 0 citations

Open access Aug 2026

Association of the Chinese visceral adiposity index with incident cardiovascular disease in cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study

Cardiovascular-kidney-metabolic (CKM) syndrome integrates metabolic abnormalities, chronic kidney disease, and cardiovascular disease (CVD), with stages 0–3 representing a critical window for primary prevention. Whether the Chinese visceral adiposity index (CVAI) adds predictive value for CVD in this population r...

Long Feng, Geng Yang, He-Song Zeng et al. · Cardiovascular Diabetology · 0 citations

Review Open access Jul 2026

Inflammation–metabolism composite (CRP–triglyceride–glucose index) predicts all-cause and cardiovascular mortality in MASLD with advanced fibrosis: Evidence from a national NHANES cohort

The observational findings suggest that CTI is associated with long-term all-cause and cardiovascular mortality in MASLD and advanced fibrosis and may help refine early risk stratification in high-risk MASLD populations.

Hao Wang, Yi-Feng Zhou, Xiaoyu Cui et al. · Medicine · 0 citations

Open access Jul 2026

Association of C-reactive protein-triglyceride glucose index and its modified indices with stroke risk in individuals at cardiovascular-kidney-metabolic syndrome stages 0–3: a population-based cohort study

The findings support the relevance of combined inflammatory, IR, and adiposity burden in stroke risk assessment, but the clinical use of complex composite indices should be balanced against screening feasibility.

Dan Yang, Yan Deng, Z. Su et al. · Cardiovascular Diabetology · 0 citations

Review Open access Jan 2026

Integrative Inflammation–Metabolism Indicator for Cardiovascular–Kidney–Metabolic Syndrome: Evaluating the C‐Reactive Protein–Triglyceride Glucose Index for Risk Stratification and Progression Across Three National Cohorts

CTI emerged as the most robust inflammatory biomarker for assessing disease severity and predicting CKM progression among multiple candidates, and its reproducible associations across national cohorts support its utility for early detection and risk stratification.

Yu-Peng Zeng, Huhao Feng, Haiying Cheng et al. · Mediators of Inflammation · 0 citations

Review Open access Jul 2026

Association of the C-reactive protein-triglyceride glucose index with cardiovascular disease and mortality in the general US population: A NHANES study

Higher CTI is associated with prevalent CVD and independently predicts increased cardiovascular and all-cause mortality and restricted cubic spline analysis revealed a nonlinear relationship between CTI and cardiovascular mortality, as well as all-cause mortality.

Zhenze Yu, Zihan Zhao, Mingzhuang Sun et al. · Medicine · 0 citations