TL;DR
Elevated PIV is non-linearly associated with thyroid autoantibody positivity, particularly TgAb, with stronger effects observed in women and hypertensive individuals, with stronger effects observed in women and hypertensive individuals.
Compared with NLR and SII, the monocyte-containing indices MLR, SIRI, and PIV showed clearer differences across thyroid functional states in Graves’ disease and may provide complementary inflammation-related information.
Pan-immune-inflammation value was found to be independently associated with increased risks of all-cause and cardiovascular mortality in individuals with diabetes, characterized by a nonlinear association and a distinct threshold effect.
Elevated RCII levels were significantly elevated in ACPA-negative RA, ACPA-positive RA, undifferentiated inflammatory arthritis, dermatomyositis, and systemic lupus erythematosus compared with HCs, with the highest levels observed in ACPA-negative RA.
Routine systemic inflammatory markers do not meaningfully distinguish autoimmune from non-autoimmune thyroid disease phenotypes, and these findings support the concept that autoimmune thyroid diseases predominantly reflect localized rather than systemic inflammatory activation.
Serum CRP levels showed a disease specific distribution across AIDs, with the highest levels in hyperinflammatory conditions such as AOSD and MAS, suggesting their potential as disease-specific biomarkers.
Tissue IgG4-positive cell infiltration was observed only among male ever-smokers and was accompanied by a distinct BAL immune-cell profile without parallel peripheral-blood changes, and should be regarded as hypothesis-generating and require validation in larger prospective studies.
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