Open access
PCK1 promotes gastric cancer progression by activating the SRC1-JAK1-STAT3 signaling axis
Jiao Nie
Tian Li
Xing-Yu Yang
Wen-Xin Bi
Wei-Sheng Lu
Jin-Ming Zhang
Chun-Mei Li
Yu-Qing Guan
Xiang Peng
Ping Wang
Feng Liu
Ru-Ling Shen
Cheng-Lin Li
Chao Du
Medicine
Abstract
Highlights • PCK1 is overexpressed in gastric cancer and promotes tumor growth and metastasis.• PCK1 activates the SRC1-JAK1-STAT3 cascade in gastric cancer cells.• The PCK1-SRC1-STAT3 pathway is a potential therapeutic target for gastric cancer.