Twenty-four-hour movement patterns relate with cardiometabolic health in adults with obesity

Abstract

Low moderate-to-vigorous physical activity (MVPA), high sedentary behavior (SB), and inadequate sleep are individually associated with type 2 diabetes (T2D) risk. However, the aggregate impact of these movement patterns remains unclear. Assess whether being aligned with 24-h movement guidelines of MVPA, SB, and sleep relates to cardiometabolic health, and compare this with the American Heart Association’s Life’s Essential 8. In a cross-sectional study, adults with obesity [n = 56 (39 F); 55.6 ± 1.1 y; 34.5 ± 0.7 kg/m2] with low 24-h movement z-scores [“aligned”; n = 28 (21 F)] were compared to those with high z-scores [“misaligned” n = 28 (18 F)]. MVPA and SB (accelerometer) and sleep (Pittsburgh Sleep Quality Index) were assessed to calculate z scores. LE8 scores were calculated according to AHA guidelines. A 120-min hyperinsulinemic-euglycemic clamp (40 mU/m2/min, 90 mg/dl) with indirect calorimetry was used to determine metabolic insulin sensitivity [glucose infusion rate (GIR)] and substrate oxidation. Pulse wave velocity and augmentation index (AIx75) were assessed at 0 and 120 min of the clamp to assess arterial stiffness. Fitness (VO2max) and body fat (DXA) were also assessed. Despite no differences in age, body fat, or VO2max, the misaligned group had higher fasting DBP, MAP, and AIx75 (P < 0.05), lower GIR (P = 0.07), and lower FFA suppression (P = 0.01). While both the z-score and LE8 related to blood pressure, only the z-score correlated with AIx75 and FFA suppression. Aligning with 24-h movement patterns related to better cardiometabolic health in people with obesity. NCT03355469.