Emerging interpretive frameworks for biospecimens, the unforeseen sensitivity of viral findings, unanticipated downstream uses of samples, and unresolved questions regarding the return of results call for updated governance capable of sustaining the ethical legitimacy of clinical research in rapidly evolving scientific landscapes.
Abstract
ABSTRACT Future-use consent frameworks enable broad research on biospecimens and now extend to human virome studies. However, virome research challenges the core assumptions underlying these consent models. We examine four dimensions of concern: evolving interpretive frameworks for biospecimens, the unforeseen sensitivity of viral findings, unanticipated downstream uses of samples, and unresolved questions regarding the return of results. These features call for updated governance capable of sustaining the ethical legitimacy of clinical research in rapidly evolving scientific landscapes.
Purpose of review HIV cure-related research at the end-of-life has created a rare opportunity to study viral persistence in tissues that cannot be safely or repeatedly sampled during life. This review examines ethical frameworks and community engagement approaches in this field from 2016 to 2026, with attention to pote...
Ali Ahmed, Whitney Tran, S. Ndukwe et al.· Current Opinion in HIV and A...· 0 citations
Elapsed time is one input, alongside technological novelty and the persistence of trust infrastructure such as CAB continuity and community reporting, into a graded governance decision that gives biobanks and research ethics committees a reproducible way to decide when broad consent for a sample collection still holds,...
P. Ikhane, S. Adebamowo, Temilola Yusuf et al.· Research Square· 1 citation
The oriGen project represents a pioneering but institutionally anchored response to Mexico's regulatory gap. Yet, viewed through the lens of contemporary scholarship, its model-private university ownership, broad individual consent, and external sequencing partnerships-stands in tension with emerging global norms for e...
Guillermo Aquino-Jarquín· Trends in Biotechnology· 1 citation
Modern biotechnology promises to cure diseases, feed the world, and address major ecological challenges. Yet a critical examination reveals that the field also faces significant ethical, reproducibility, and governance challenges that deserve rigorous scrutiny. Drawing on documented cases from gene therapy pricing cont...
BACKGROUND
Biobank consent models are contested globally. The EU's GDPR Article 89, the US revised Common Rule (2018), and international guidelines offer divergent approaches to balancing participant autonomy and research efficiency. Despite ongoing policy debate, empirical evidence comparing research ethics oversight...
Chi-Hung Huang, Chih-Shung Wong, Henry Hsin-Chung Lee et al.· BMC Medical Ethics· 0 citations
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