Reconstruction robustness of liver-referenced adaptive thresholding for 68Ga-PSMA-11 PET/CT volumetry: a comparative analysis of systematic bias and individual-patient variability.
Oct 2026· Annals of Nuclear Medicine· 0 citations· 21 references
Medicine
TL;DR
These findings support further evaluation of liver-referenced thresholding for standardized PSMA-TV assessment in longitudinal and multicenter settings and support further evaluation of liver-referenced thresholding for standardized PSMA-TV assessment in longitudinal and multicenter settings.
PSMA PET/CT using 18F‑DCFPyL and 68Ga‑labelled tracers is central to prostate cancer staging, but 68Ga‑PSMA may show reduced sensitivity and quantitative accuracy, partly due to respiratory motion and lower spatial resolution. Device-based motion‑correction methods have limitations. Data‑driven gating (DDG) offers a ha...
Adam Farag, C. Felder, D. Hussey et al.· EJNMMI Reports· 0 citations
The primary quantitative endpoint, the Ki value, remains highly robust across all evaluated framing protocols, software platforms, and reconstruction algorithms and facilitates cross-center data harmonization and clinical standardization for multi-center dynamic 18F-FDG PET/CT.
Ya-Rong Zhang, X. Wumener, Mao-Qun Zhang et al.· Frontiers in Oncology· 0 citations
The purpose of this study was to develop and validate lesion identification in oncologic nuclear imaging (LION), an open-source PET-only tumor segmentation pipeline for [18F]FDG and prostate-specific membrane antigen (PSMA)-targeted PET/CT, and to investigate how training data characteristics influence segmentation per...
M. Pires, S. Gutschmayer, E. Bergalla et al.· Journal of Nuclear Medicine· 1 citation
PURPOSE
Despite remarkable auto-segmentation performance and growing clinical adoption, models frequently fail to generalize beyond the training distribution. Therefore, this study aimed to develop and validate an uncertainty-aware segmentation pipeline that yields high delineation accuracy for liver cancer patients an...
D. Langner, C. Gani, S. Boeke et al.· Radiotherapy and Oncology· 0 citations
Optimize CT acquisition protocols reduced radiation dose while preserving the evaluated objective image quality metrics in the cranial, thoracic, and upper abdominal regions, and was identified as a candidate protocol for subsequent clinical and reader performance validation.
D. Kostova-Lefterova, F. Simeonov, D. Hitova-Topkarova et al.· Biomedical engineering and p...· 0 citations
PURPOSE/OBJECTIVES
Optimal implementation of gadoxetate disodium injection (GDI) in liver-directed MR-guided online adaptive radiotherapy (MRgART) remains poorly characterized. Herein, we evaluated the impact of GDI on physician-reported imaging metrics and quantitative contouring variability during liver MRgART planni...
A. A. Kassardjian, B. Maraghechi, Cheng-Yu Shi et al.· Practical Radiation Oncology· 0 citations
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