G2P Explorer: A Native iOS Framework for Residue-Level Genomics to Proteomics Visualization and Structural Variant Interpretation

Abstract

Genetic testing reports coding variants far faster than they can be interpreted, and placing a variant in its biophysical context, the domain it perturbs, whether its residue is buried or exposed, whether it lies near a disulfide bond or a predicted binding pocket increasingly requires projecting it onto a three dimensional protein model. The Genomics 2 Proteins (G2P) portal unifies the gene-to-structure identifier chain with a dense, residue indexed annotation table, but its visualization layer presumes a desktop browser and is awkward at the bedside, in the classroom, or in the field, where a phone or tablet is often the only device. We present G2P Explorer, a native iOS framework that consumes the public G2P REST API on device, parses its seventy one column tab separated feature tables without loss of fidelity, and presents the result through six interlinked modules sharing a single observable view model. Beyond porting, it contributes a SwiftUI Canvas multi-track sequence renderer, an on device reconstruction of the portal's unavailable isoform alignment route, a bidirectional Swift JavaScript structural bridge that absorbs the AlphaFold model file versioning scheme, and a fault tolerant ingestion layer that parses semi structured free text and distinguishes absent annotations from zero. Each searched protein is cached on device after the first fetch, so it reopens instantly and works offline, and the embedded structural view is drawn in a reduced form suited to a small screen. Across six proteins spanning 189-1{,}863 residues, the framework sustains interactive frame times (3.1-16.6\,ms) and modest memory (16-72\,MB). G2P Explorer is an open, reproducible mobile companion to the G2P portal for hypothesis generation, teaching, and on the go variant interpretation.