Transcriptomic Changes and Biomarkers in Barrett’s Metaplasia, Dysplasia and Cancer

Abstract B039: Genomic and epigenomic complexity underlies barrett’s esophagus progression to adenocarcinoma

This study defines the role of epigenetic reprogramming in BE-to-EAC progression by integrating spatial transcriptomics, single-cell analyses, and functional modeling, and demonstrates that enhancer activation correlates with transitions from stable epithelial identity to highly plastic, dysplastic, and malignant pheno...

P1.108. Molecular Determinants of Tumor Morphology in Esophageal Adenocarcinoma

The first validated morpho-molecular classification of Esophageal adenocarcinoma is reported, with the transitional and signet ring signatures associated with worse prognosis compared to tumors with a glandular signature.

Histopathological and Molecular Characterization of Potentially Malignant Oral Disorders for Early Diagnosis and Prognostic Assessment

Potentially malignant oral disorders (PMODs) represent a critical group of lesions with a well-documented risk of transformation into oral squamous cell carcinoma, necessitating early and precise diagnostic approaches to improve patient outcomes. This study aims to integrate histopathological evaluation with molecular...

analysis of microsatellites on multiple chromosome regions in dysplasia and squamous cell carcinoma of the esophagus

BBS5 as a robust prognostic biomarker in esophageal squamous cell carcinoma: validation in two independent cohorts.

Early esophageal squamous neoplasia and the microbiome: evidence, mechanisms, and early-detection potential

Esophageal squamous cell carcinoma (ESCC) remains a major cause of cancer mortality, largely because most patients are diagnosed at an advanced stage. High-grade intraepithelial neoplasia (HGIN) represents an important and clinically actionable precancerous stage in the ESCC pathway, during which timely detection and e...