Novel imaging methods that may extend 2D spatial analyses into 3D modelling, and the complementary applicability of deep-learning-based computational pathology are discussed, as well as the advantages, limitations and applications of spatial omics technologies in kidney research.
Heterogeneous tumor microenvironment (TME) in lung cancer plays a crucial role in disease progression and resistance to therapy. Despite advances in single-cell and bulk omics profiling, these methods often overlook spatial context, which is vital for understanding cell-cell interactions and regional heterogeneity. In...
Sanjukta Dasgupta, Subhayan Das, Shouvik Saha· Current Problems in Cancer· 0 citations
Abstract Background Multi-omics research is reshaping precision nephrology by linking genetic susceptibility, epigenetic regulation, transcriptional state, protein abundance, metabolic activity and spatial tissue context within integrated analytical frameworks. Methods We critically reviewed recent technological advanc...
BACKGROUND
A comprehensive understanding of the complexity and heterogeneity of the tumor microenvironment (TME) is critical for advancing cancer treatment. Recent advances in spatial omics technologies have opened new avenues for an in-depth exploration of the TME. By integrating high-resolution spatial information fr...
Xia Lei, Xuan Cui, Y. Ni et al.· Journal of Advanced Research· 0 citations
VirTues-derived biomarkers predict anti-PD-L1 chemo-immunotherapy response and stratify disease-free survival in an independent cohort, outperforming state-of-the-art biomarkers derived from the same datasets and current clinical stratification schemes.
Johann Wenckstern, Eeshaan Jain, Benedikt von Querfurth et al.· Nature· 4 citations
A post-spatial profiling workflow that combines the Xenium platform with iterative indirect immunofluorescence imaging (4i) on formalin-fixed paraffin-embedded (FFPE) human brain tissue to capture key pathological features for Alzheimer’s disease (AD) and facilitate cell segmentation is reported.
Berke Karaahmet, Tsering Lama, An-Qi Wang et al.· bioRxiv· 0 citations
Pancreatic ductal adenocarcinoma (PDAC) is a complex disease characterized by high levels of cellular heterogeneity and pronounced microenvironmental remodelling. Dynamic changes during its initiation and progression contribute to resistance to conventional therapies. Building upon key molecular catalogues established...
S. Bae, A. Tsirigos, Ji-Min Min et al.· Experimental and Molecular M...· 0 citations
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