It is shown that ADAM12 is highly upregulated in the stroma of pancreatic cancer patients and that its expression correlates with stromal marker expression and stromal gene signatures, and bioinformatics as well as in vitro experiments suggest that TGF-β signaling mediates the upregulation of ADAM12.
The present review focuses on and discusses the key components of the PDAC TME, with particular emphasis on ECM remodeling, stromal components, their impact on tumor progression and therapeutic resistance, and emerging strategies to target these processes.
B. M. Gomes, P. L. P. Xavier· Biochemical Society Transact...· 0 citations
miRNAs are small molecules which influence cellular function by regulating the expression of mRNA. They control various stages of the cell’s existence, including differentiation, proliferation and finally death. In cancer cells, miRNAs can become dysregulated, enabling the cell to escape growth suppression and resist...
Mateusz Gotowiec, Marta Wojtkiewicz-Gotowiec, K. Marcinkowska et al.· Journal of Cancer Research a...· 0 citations
The study reveals that glycosylation and phosphorylation of CD44 regulate its ligand-binding affinity and cell migration, and suggests that targeting CD44, particularly its variant forms, could disrupt cancer stem cell maintenance and metastasis, offering potential therapeutic avenues.
Hyun-Ji Oh, Seung-Tae Kim, Hyun-Jin Kim et al.· Experimental and Molecular M...· 1 citation
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