The role of the UPS in glial cells in various neurodegenerative diseases is reviewed, and how studying glial cell function might provide essential information in unraveling mechanisms of neurodegenerative diseases is discussed.
Autophagy-Lysosomal Pathway (ALP) dysfunction has emerged as a prominent mechanism underlying neurodegenerative disease. Given its central role in facilitating cellular clearance of misfolded proteins, damaged organelles and other cellular debris, the ALP is vital for cellular health and survival. In mature neurons, wh...
Samantha R. McDonough, Aditya K. Rao, Jacqueline M. McAleer et al.· Molecular Neurodegeneration...· 0 citations
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease are among the progressive disorders of the nervous system that are characterized by the gradual destruction of neurons, the accumulation of misfolded proteins, and the limited effectiv...
S. Mohammad, A. Vasudevan, G. Oriquat et al.· Behavioural Brain Research· 0 citations
BACKGROUND
Microglia, the resident immune cells of the central nervous system (CNS), maintain brain homeostasis and respond to pathological insults. Microglial dysfunction has been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and multiple scle...
R. Jaganathan, Srilakshmi Vijayakumar, Yinchi Chen et al.· Neurobiology of Disease· 0 citations
Alzheimer's disease (AD) is a progressively debilitating neurodegenerative condition characterized by the accumulation of amyloid-β (Aβ), tau pathology, synaptopathy, and neuron loss. Recent studies suggest that Neuroinflammation is a critical part of the disease process rather than an accompanying feature of the menti...
Almas Meheboob Pathan· International Journal of The...· 0 citations
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