AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
A new strategy to generate human cerebral organoids with vasculature and microglia-like cells using genetic code expansion technology (GCE-T) via site-specific protein engineering is presented, opening a new avenue to advance organoid research and applications.
An enhanced human induced pluripotent stem cell (hiPSC)-derived cerebral organoid (CO) platform optimized to mitigate core hypoxia for over 200 days enables longitudinal modeling of neural-immune crosstalk in age-related and neuroinflammatory CNS disorders.
This human iPSC-derived tumor–brain organoid platform provides a reliable and scalable system for studying complex tumor-neural interactions and exploring therapeutic approaches that aim to eliminate the tumor while preserving neural function.
The development of brain organoid research is reviewed and recent advances including neuronal activity measurements, neural circuit models using assembloids and connectoids, reconstruction of human-enriched cell types and gene programs, analyses of inter-individual variability, toxicological studies, disease modeling,...
A protocol for generating vascular organoids (VOs) via orthogonal forward programming of hPSCs via orthogonal forward programming of ETV2 and NKX3 using doxycycline-inducible activation of the transcription factors ETV2 and NKX3.
The goal is not to replicate the brain in miniature, but to reconstruct its organizing principles in an experimentally accessible system, offering new insights into human neural complexity while advancing neuroscience and medicine.
A co-maturation protocol that robustly generates glutamatergic neuronal networks containing hiPSC-derived microglia and induced the typical ramified microglia morphology and characteristic microglia-neuron interactions is presented.
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