This review summarizes current knowledge of exosome biogenesis, molecular composition, and mechanisms of action, alongside commonly used isolation and characterization strategies, and discusses both natural and engineered exosomes, highlighting advances in surface modification, hybrid vesicle construction, and selective cargo loading.
This narrative review integrates current knowledge of exosome biology, diagnostic and therapeutic applications, and engineering strategies and outlines future priorities for advancing exosome-based technologies toward precision medicine.
Chin-Yin Lin, Chih-Yang Lin, W. Shyu et al.· International Journal of Mol...· 0 citations
This review delves into exosome isolation techniques, the regulatory mechanisms underlying their biogenesis and secretion, and their dual roles in cancer progression, metastasis, and tumor immunity, concluding with a discussion of the challenges and future directions in their clinical translation.
Ying-Ying Li, Ya Gao, Yan-Hong Wang et al.· Frontiers in Cell and Develo...· 0 citations
This review provides a comprehensive overview of EVs' biology, covering their biogenesis, biochemical composition, isolation strategies, and characterization methodologies, and puts emphasis on the functional roles of EVs in cancer, cardiovascular diseases, autoimmune disorders, intestinal fibrosis, and neural repair.
E. I. Torunoğlu, Zeynep Betul Sarı, Muhammed Emin Sarı et al.· Biotechnology and Bioenginee...· 0 citations
This review details the role of tumor derived exosomes in shaping an immunosuppressive TME, especially their capacity to modulate T-cell function, polarize myeloid cells, and influence immune checkpoint signalling, and discusses emerging therapeutic strategies aimed at intercepting or reprogramming exosomal cargo.
RamaRao Malla, G. Nagaraju· Biochemical Pharmacology· 0 citations
This review critically examines the current state of exosome-based therapeutics, focusing on isolation methods, engineering strategies, and clinical translation through early 2024, holding promise in oncology, cardiovascular disease, neurological disorders, and regenerative medicine.
Yuvaraj Nitin Sharma· Global Journal of Research i...· 0 citations
Convergence of AI-driven manufacturing optimisation, multimodal engineering platforms, and international regulatory harmonisation defines the translational roadmap for exosome-based medicines over the coming decade.
M. Shkurnikov, Alexander Tonevitsky· Current Medicinal Chemistry· 1 citation
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