Review
Open access
Mesenchymal stem/stromal cell senescence in aging and regenerative medicine: a systematic review
Letícia Odaguiri Watanabe
Luana Roleto Cardoso
Johnny Carvalho da Silva
Larissa Di Carvalho
Vitoria Castro
J. L. Carvalho
E. Guerra
Taia Maria Berto Rezende
Medicine
Abstract
These cells can be isolated from a wide range of human tissues, including bone marrow (BM-MSCs), adipose tissue (AD-MSCs), dental tissues, such as dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs), as well as umbilical cord cells (UC-MSCs), including Wharton’s jelly–derived MSCs (UC-MSCs-WJ) and umbilical cord blood–derived MSCs (UC-MSCs-CB) (Kern et al. 2006; Heo et al. 2016). The therapeutic potential of MSCs is closely linked to their functional properties, including their capacity to migrate to sites of injury, modulate immune responses, and promote tissue repair predominantly through paracrine signaling, in addition to limited proliferative and differentiation potential (Zuk et al. 2001).