TL;DR
Preliminary findings require validation in larger, prospective, multicenter cohorts before the sinoatrial (SA) node can be considered a formal organ at risk in RT planning, while AV node dose was linked to PR prolongation rather than AF.
It is suggestive that PH following thoracic RT may occur through a pathophysiological process distinct from RT-induced pulmonary fibrosis, as well as associated with PA radiation dose.
PURPOSE To investigate the association between cardiac conduction system dosimetry, specifically the sinoatrial node (SAN), for new-onset electrocardiogram (ECG) abnormalities in breast cancer (BC) patients undergoing intensity-modulated radiotherapy (IMRT). METHODS We retrospectively reviewed 91 BC patients treated...
Introduction: Cardiovascular diseases (CVD) are common complications among cancer survivors treated with radiotherapy (RT). Breast cancer (BC) survivors can develop a variety of cardiotoxic complications related to cardiac radiation exposure that occurs months to years after RT, with atrial fibrillation (AF) often repo...
Introduction Thoracic radiotherapy is integral to multimodal treatment for malignancies involving the thorax, but the literature on the burden of reported atrial fibrillation (AF) after thoracic radiotherapy and its relationship with cardiac substructure dose exposure has not been systematically synthesized. Methods We...
BACKGROUND Radiation therapy (RT) is highly efficacious in treating thoracic malignancies. However, RT has been linked to potential cardiotoxicity. Yet, the long-term incidence, severity, and implications of HTN-development post-RT are unknown. METHODS Leveraging a large US-based Comprehensive-Cancer-Center-cohort of...
Improved childhood cancer survival has been accompanied by substantial late morbidity and mortality related to cardiotoxic cancer therapies. We conducted a retrospective study of childhood cancer survivors (CCS) diagnosed before age 21 and followed at The Children's Hospital at Montefiore (CHAM). Collected data include...
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