Stimulation modulates gene-linked cell assemblies in the human brain.

Haley Moore M. Dehnad A. Freelin B. Granger S. Subramanian Tjitse van der Molen Ashwinikumar Kulkarni S. Berto B. Lega G. Konopka

Aug 2026 · Nature · 0 citations · 80 references

Medicine

TL;DR

An ex vivo platform that integrates microelectrode array stimulation with simultaneous recording and single-nucleus genomics from resected temporal cortex obtained from patients undergoing neurosurgery finds that stimulation strengthens cell assemblies and then linked this effect to cell-type-specific gene regulatory networks.

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