A series of acceptor-π -donor based molecular NIR probes, composed of rhodanine in conjugation with coumarin or carbostyril nucleus, which can be tuned due to their versatile structural scaffold to evolve as promising NIR imaging probes for the detection of AD biomarkers.
By fine-tuning the amphiphilicity of a hemicyanine scaffold to place its log P within the appropriate range, P3 is identified as a wash-free NIRF probe for Aβ aggregates and provides a wash-free, high-affinity NIRF probe for Aβ imaging.
Xue-Qi Zhao, Run-Dong Liang, Yao Li et al.· Molecules· 0 citations
Indolizine is established as a promising scaffold for the development of complementary fluorescence imaging tools for AD-related ex vivo tissue studies and highlights the utility of ex vivo tissue-based screening for fluorescent-probe discovery.
I. Park, Kyeonghwan Kim, Sunhee Lee et al.· ACS Chemical Neuroscience· 0 citations
Selective near-infrared fluorescent probes for amyloid β aggregates are of considerable interest as molecular imaging tools for the diagnosis and study of Alzheimer's disease. Herein, we describe the rational design and synthesis of DDNP-type donor-π-acceptor fluorophores incorporating a fixed N,N-dimethylamino donor g...
Matic Rogan, L. Blinc, Luka Rejc et al.· Bioorganic chemistry (Print)· 0 citations
The diazapyridinophane scaffold is established as a viable first-generation platform for blood–brain barrier (BBB)–permeable Mn2+ MRI contrast agents and both the bifunctional chelators and their Mn2+ complexes exhibit appreciable affinity for Aβ aggregates.
T. El Sayed, Akhil Patel, Ke-Rui Xu et al.· Inorganic Chemistry Frontier...· 0 citations
A review examines the potential of nanomaterial-based sensing strategies for developing clinically relevant neurodiagnostics, categorizes them systematically, and links them to biomarker profiles for AD and PD.
Shajahan Azeez, Raj Kumar Chinnadurai, Saravanaraman Ponne et al.· International review of neur...· 0 citations
Development of precise, non-invasive, and dynamic methods for detecting amyloid-β (Aβ) aggregates is of vital importance for the early diagnosis and therapeutic evaluation of Alzheimer’s disease (AD). Recently, the Akalumine (AkaL)-based firefly bioluminescent probe has emerged as a promising tool for deep-tissue Aβ...
Shuang-Qi Pi, Ya-Jun Liu· Journal of Physical Chemistr...· 0 citations
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