The Therapeutic Potential of Curcumin and Its Analogs in Myocardial Fibrosis: A Comprehensive Review

Curcumin in Fibrosis Treatment: A Review

Abstract Fibrosis, marked by excessive accumulation of extracellular matrix (ECM) components, ultimately leads to dysfunction and failure of multiple organs, yet effective therapeutic options remain scarce. Curcumin (CUR), a naturally occurring polyphenol with diverse biological activities, has emerged as a promising c...

Natural Products Targeting Myocardial Fibrosis: Pharmacological Basis, Molecular Mechanisms and Translational Barriers

Future directives necessitate rigorous botanical authentication, pharmacokinetic/pharmacodynamic profiling, and adoption of human-relevant models, such as induced pluripotent stem cell-derived cardiomyocytes, to bridge the bench-to-bedside gap.

Curcumin as a natural therapeutic agent for osteoarthritis: molecular mechanisms, preclinical evidence, clinical applications, and future perspectives.

Molecular insights of a Unani formulation in targeting fibrosis-associated diseases

This PUF is considered as a potential integrative therapeutic approach for fibrosis-related diseases and for aggressive cancers with fibrosis, and is expected to target both tumour cells and the fibrotic tumour micro-environment, thereby integrating ethnopharmacological knowledge with molecular rationality.

Antifibrotic mechanism of curcumin and its therapeutic potential in multi-organ diseases

Fibrosis is the outcome of chronic diseases and manifests as an abnormal repair process in which normal parenchyma is progressively replaced by deposited extracellular matrix. It leads to organ dysfunction and is associated with high morbidity, disability, and mortality, thereby becoming a major public health concern....

Breaking the cycle of fibrosis: Ferroptosis as a therapeutic target (Review)

Fibrosis, characterized by abnormal deposition of extracellular matrix, is a chronic disease that progressively remodels tissues, leading to organ failure, earning it the moniker the 'silent killer' of organ function. Recently, ferroptosis, a novel form of regulated cell death, has garnered attention in research; its m...