Open access
Efficacy and safety of bridging therapy prior to CAR T-cell therapy in relapsed or refractory multiple myeloma.
M. Wesener
U. Demel
T. Pabst
R. Teipel
Anca-Maria Albici
B. von Tresckow
M. Teichert
A. Boquoi
T. Holderried
Friederike Schmitz
Fabian Müller
Friedrich-Linus Rößiger
M. Hoffmann
N. Schub
N. Tovar
A. Oliver-Cáldes
N. Kroger
Ben-Niklas Baermann
Stephan R. Bohl
D. Fandrei
V. Vučinić
I. Strassl
F. Stölzel
C. F. de Larrea
Ulrich Keller
A. Busse
M. Merz
N. Gagelmann
Medicine
Abstract
Disease burden at the time of BCMA-directed chimeric antigen receptor (CAR) T-cell infusion is a key determinant of outcome in relapsed or refractory multiple myeloma (RRMM). Bridging therapy is frequently administered between leukapheresis and infusion to prevent disease progression, yet its clinical impact remains unclear. We conducted a multicenter real-world cohort study of 399 patients with RRMM treated with BCMA-directed CAR T-cell therapy, including 348 (87%) who received bridging therapy. Bridging therapy recipients had more advanced and biologically adverse disease, including higher rates of high-risk cytogenetics and penta-class refractoriness. Bridging efficacy varied substantially by regimen (P.