Development of a Ce-BDC-NH2/MWCNTs Composite-Modified Electrode for Enhanced Electrochemical Detection of Enrofloxacin

Abstract

Due to their high porosity, abundant active sites, and reversible Ce3+/Ce4+ redox couple, cerium-based metal-organic frameworks (Ce-MOFs) have garnered more attention in recent years. Benefiting from their porous architecture, accessible active sites, and excellent electrochemical characteristics, these frameworks have shown great potential in catalysis and electrochemical sensing. Building upon these advantages, a Ce-BDC NH₂/MWCNTs composite-modified glassy carbon electrode (GCE) was designed and fabricated to achieve sensitive electrochemical detection of enrofloxacin. The synergistic constructed by multi-walled carbon nanotubes (MWCNTs) and Ce-BDC NH₂ effectively boosts the conductivity of composites, thus endowing the electrode with superior sensing selectivity and sensitivity. The proposed sensor exhibits a well defined electrochemical response within a scan rate range of 30-150 mV/s, with an optimal detection pH of 7.00. The prepared sensor showed linear response within the concentration range of 2-70 μM enrofloxacin and achieved a low detection limit of 8.64nM. Additionally, this sensor possesses strong anti-interference capacity toward typical interferents including LA, COA and NA. In addition, the fabricated electrode maintains over 85% of its initial response after 21 days, indicating outstanding long term stability and promising practical applicability.