Study of different aspects of polyendocrine metabolic ovarian syndrome in females of reproductive age group

Abstract

Background: PMOS is most common hormonal disorder in females of reproductive age group. In PMOS many pearl sized cysts are formed in the ovaries. These cysts contain immature eggs. High LH, low FSH, high Testosterone in PMOS causes changes in physical appearance, irregularity in menstrual cycle and if not treated in time, leads to diabetes and strokes, obesity, mood disorder, endometrial cancer and sleep apnoea. The aim of the present study was to find out the clinical features, biochemical and hormonal profile of patients with PMOS. Method: An observational, comparative study was conducted in the Department of Biochemistry in collaboration with the Department of Obstetrics and Gynaecology, Govt. Medical College and Hospital, Amritsar after taking approval from institutional ethical committee. The study group included 25 patients clinically diagnosed as patients of polycystic ovary disease, between age group 14-35 years. 25 age and sex matched healthy volunteers were included as control. Result: Levels of LH, Prolactin, Testosterone were increased significantly in PMOS patients whereas changes in TSH were not significant. The FSH was significantly lower in the study group. Levels of Insulin and C-peptide were raised in PCOS patients. Conclusion: From present study it is observed that PMOS patients are usually overweight, have menstrual irregularities, difficulty in conception, have oily skin, acne, hirsutism, hyperandrogenaemia, insulin resistant and have altered LH to FSH ratio, patients also have sleep disturbances, mood swings. The present study concludes that PMOS not only affect the physical quality of life, but it also affects mental and social life.