TL;DR
Hypoxia/reoxygenation assays using H9C2 rat cardiomyocytes confirmed the upregulation of Myc and Rnf115 during early MIRI, aligning with bioinformatics trends.
This study aimed to screen and identify core hypoxia‐ischemia‐related genes associated with myocardial infarction (MI).
Acute myocardial infarction (AMI) is a major global health burden. Current diagnostic reliance on high-sensitivity cardiac troponin (hs-cTn) is limited by its lack of disease specificity and inability to reveal upstream molecular and immune mechanisms. This study aimed to identify robust core genes and their functional...
In vivo, miR-221-3p antagomir pre-treatment restored CPT2, reduced reactive oxygen species (ROS) and NET-associated markers, lowered apparent infarct burden, and improved acute cardiac function, and identified 18 metabolites associated with IHD after false-discovery-rate (FDR) correction.
The molecular mechanisms underlying heart failure (HF) following myocardial infarction (MI) (HF-MI) remain incompletely understood, and discoveries from whole-transcriptome profiling hold significant promise for disease prevention and treatment. Whole-transcriptome sequencing was performed on whole blood f...
In vivo qPCR results verified that the mRNA expression of CEBPB and PPP1R15A was significantly elevated in myocardial tissues of AMI model mice compared with the sham group, and have high research potential for exploring the molecular mechanism of myocardial ischemic injury.
Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide, highlighting the need for novel complementary biomarkers. By integrating bulk and single-cell transcriptomic data with machine learning approaches, calmodulin-related genes associated with AMI and explored their immune-metabolic...
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