Causal relationship and pathogenic mechanism analysis of breast cancer and coronary heart disease based on mendelian randomization and transcriptome data analysis
The genetic causal relationship between BC and CHD in Asian populations is established for the first time, and the inflammation-immune-metabolism molecular axis mediating comorbidities is revealed, revealing the inflammation-immune-metabolism molecular axis mediating comorbidities.
BACKGROUND
Endocrine-disrupting chemicals (EDCs) are linked to coronary heart disease (CHD), but underlying mechanisms remain unclear. We aimed to identify EDC-related genes and evaluate their causal roles in CHD.
METHODS
We curated EDC-related genes from a compound-gene interaction database and integrated them with...
Tao Yao, Yun-Lu Lin, Luoxiang Fang et al.· Food and Chemical Toxicology· 0 citations
An integrated cross-omics analysis identifies novel genetic loci and, crucially, uncovers specific nutrient-related metabolic pathways that mediate genetic risk in Aortic aneurysm and its subtypes.
Han-Xi Wang, Junjie Cheng, Jia-Li Yao et al.· Frontiers in Nutrition· 0 citations
Objective This study used two-sample Mendelian Randomization to investigate the causal link between multiple biological aging indicators and vascular disease. Methods Summary genetic data was obtained from genome-wide association studies (GWAS) focusing on aging-related exposures and various vascular disease outcomes....
Hao Yan, Shan Wei, Hui Hui et al.· Clinical and applied thrombo...· 0 citations
Background Coronary atherosclerosis (CA) is a leading cause of cardiovascular morbidity and mortality worldwide. This study is aimed at identifying candidate plasma proteins and potential therapeutic targets for CA. Methods We performed a proteome‐wide Mendelian randomization (MR) analysis using integrated protein quan...
Da Gao, Hai-Yan Lin, Sheng-Jie Wang et al.· Cardiovascular Therapeutics· 0 citations
Post-operative cerebral infarction represents a severe complication following glioma surgery, yet the molecular mechanisms underlying this association and its potential relationship with tumorigenesis remain unclear. This study aims to explore the molecular connections between cerebral infarction and glioma through two...
