Skip to content
Open access

An Explainable AI-Driven Framework for Integrating Diverse Health Data to Enhance Predictive Accuracy and Clinical Interpretability

Aug 2026 · Journal of Intelligent Decision Making and Information Science · 0 citations · 27 references

TL;DR

A framework through XAI to incorporate various health data sources such as electronic health records, medical imaging, laboratory reports, and wearable sensor information, which can be integrated in the context of achieving higher predictive performance in disease prediction and treatment stratification, as well as decision-making transparency.

Abstract

The potential benefits of artificial intelligence (AI) in healthcare cannot be overstated, and there is a lot of potential to ensure that patients can receive optimal care through early disease detection, personalized treatment options, and more. Nonetheless, the used advanced AI models have remained largely hindered by their black-box nature, which is why they are usually called the black-box problem. Such a lack of transparency undermines trust amongst clinicians and regulatory agencies so as to restrict the effective utilization of such powerful tools practically. Explainable Artificial Intelligence (XAI) appears as a decisive way out in such an essential challenge. Increasing clarity and explanation of complex machine learning models have the direct benefits of fostering more trust, as well as enhancing diagnostic accuracy and the successful overall results of patients. The effectiveness with which XAI can provide transparent and decipherable information toward AI-derived predictions is not only a technical contribution, but a necessary match with demands of ethical and clinical concerns in an area where decisions have significant implications. This means that the XAI capacity will become a rising need in a regulatory and ethical Trias handled and measured in an environment where the outcomes of decisions have great implications on the outcomes of patients. This report is an account of a framework through XAI to incorporate various health data sources such as electronic health records, medical imaging, laboratory reports, and wearable sensor information, which can be integrated in the context of achieving higher predictive performance in disease prediction and treatment stratification, as well as decision-making transparency.

Read PDF

Similar papers

Review Open access Aug 2026

Advancing Trustworthy Clinical Decision Support Through Explainable Artificial Intelligence: A Framework for Transparent, Interpretable, and Ethical Healthcare Analytics

A narrative review of the evolving image of XAI as a tool to create trustworthy clinical decision support systems and how it can be performed based on the concepts of transparency, interpretability and moral decision-making concludes that explainability is a fundamental component to the use of AI in everyday clinical p...

Rakesh Venuturumilli, Amoli Singh, Hemanshi Dhaduk et al. · 0 citations
Review Open access Aug 2026

Explainable AI in Healthcare: A Comparative Analysis of Interpretability Techniques for Clinical Decision Support Systems

It is concluded that explainable artificial intelligence improves trust, reliability, and accountability in healthcare systems and is a prerequisite for successful integration of intelligent technologies into clinical practice.

Riya Jacob K · 0 citations
Review Open access Jul 2026

A scoping review of explainable artificial intelligence for medical multimodal data.

Suggestions are provided for the field to transition from individual and post-hoc XAIs toward intrinsically explainable designs where the reasoning logic is built directly into the model architecture to ensure that AI outputs align with human-centric clinical workflows and applications.

Kai Hu, Xing-Yue Fu, Yupeng Zhang et al. · 0 citations
Review Open access Aug 2026

Explainable Artificial Intelligence for Tabular Data in Healthcare: A Systematic Review of Methods, Evaluation, and Applications

This systematic review provides a comprehensive analysis of XAI methods specifically applied to tabular healthcare data for classification tasks, revealing that SHAP remains the dominant post-hoc method, achieving strong model fidelity but showing inconsistent alignment with clinical expert reasoning.

Angelower Santana-Velásquez, M. B. Salazar-Sánchez · 0 citations
Jul 2026

A Reproducible Protocol for Developing and Evaluating Explainable Artificial Intelligence Frameworks in Healthcare Analytics.

A reproducible experimental approach to developing and evaluating explainable AI systems for healthcare analytics that integrates the steps of data preprocessing, predictive modeling, interpretation generation, and evaluation into one seamless workflow that can be applied to both structured clinical data and medical im...

Yashwant Dongre, Deepali A. Godse, Prawit Chumchu et al. · 0 citations
Review Open access 2024

The Emergence of Explainable AI in Modern Decision Systems

A methodology is advanced to embed explainability in the AI decision-making process, starting from data preprocessing to generating explanations and human evaluation, and the results highlight the potential of explainability to enhance human comprehension and foster responsible use of AI systems in high-stakes decision...

Mahabala H. N. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.