TL;DR
The TFAP4-CDK1 axis is established as a critical driver of malignant progression in CRC and Targeting this pathway could lead to the development of novel interventions for CRC.
A seven-gene immune-related prognostic signature that, combined with clinicopathological parameters, provides a robust tool for individualized survival prediction and may guide precision management in CRC patients is developed and validated.
Colorectal cancer is a common gastrointestinal malignancy with a high mortality rate. Cancer cells must resist all forms of cell death to progress, and these death-related genes have been shown to have a fundamental impact on cancer development and metastasis. However, these cell death-related genes are still rar...
EZH2, CDK1, and AURKA constitute an internally validated prognostic risk signature in PCa that links cell cycle dysregulation to an immunosuppressive tumor microenvironment and provides clinically actionable risk stratification and highlights candidate therapeutic targets in prostate cancer.
This study identified five lung cancer-associated hub genes and provided preliminary evidence that resveratrol may modulate their expression, and provides a multi-level molecular framework for further investigation of resveratrol-responsive networks in lung cancer.
Investigation of MS-related prognostic genes and their potential biological relevance in CRC progression finds potential clues for future studies of CRC prognosis and MS-related tumor biology.
The comorbidity of psoriasis and inflammatory bowel disease (IBD) is well-established, yet the shared molecular mechanisms, particularly the role of apoptosis, remain insufficiently explored. This study aims to identify key apoptosis-related genes that link these two diseases. Microarray data from the GEO...
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