Open access
Fatal Infection with Dengue Virus and Avian Orthoavulavirus 1 in Traveler Returning from Saudi Arabia to France, 2025
M. Salmona
Salomé Schlupmann
M. Mailhe
Dorothée Chopin
Q. Richier
Karine Lacombe
L. Bouadma
J. Timsit
V. Bondet
Q. Le Hingrat
J. Le Goff
J. Sugrue
Darragh Duffy
Olivier Schwartz
Michael White
Valérie Paradis
Franck Verdonk
F. Lescure
Marie Jaspard
Medicine
Abstract
A previously healthy 26-year-old man died of hemorrhagic fever with fulminant hepatitis and shock 36 hours after returning to France from Mecca, Saudi Arabia. Postmortem analyses detected low-level dengue virus RNA and positive NS1 antigen along with unexpected extremely high-titer disseminated velogenic avian orthoavulavirus 1 infection with elevated systemic cytokine responses.