Review
Open access
Short-chain fatty acid-producing commensals: Key modulators of AD neuroinflammation via the microbiota-gut-brain axis
Zong-Xin Ling
Sheng-Yu Huang
Yi-Wen Cheng
Xia Liu
Xiao-Cui Xu
Yang-Tian Chen
Ping-Ping Hu
Ling-Bin Wu
Guang-Yong Cai
Sep 2026 · Current Research in Microbial Sciences · Vol 11, pp. 100660 · 1 citation
· 298 references
Medicine
TL;DR
Depletion of SCFA-producing gut bacteria is a consistent feature of Alzheimer’s disease across diverse populations and restoring SCFA-mediated gut-brain communication represents a promising disease-modifying strategy for early AD intervention.
Abstract
Highlights ● Depletion of SCFA-producing gut bacteria is a consistent feature of Alzheimer’s disease across diverse populations.● SCFAs suppress neuroinflammation via GPCR signaling, HDAC inhibition, and metabolic reprogramming of microglia and astrocytes.● SCFAs modulate Aβ deposition, tau pathology, and synaptic integrity through multi-layered regulatory mechanisms.● Restoring SCFA-mediated gut-brain communication represents a promising disease-modifying strategy for early AD intervention.