Compared to existing DP text generation baselines, Term2Note substantially improves both fidelity and utility, without relying on label distribution assumptions, highlighting its effectiveness as a practical privacy-preserving alternative to real clinical notes.
Abstract
In high-stakes domains such as healthcare, privacy concerns severely limit the use of real-world training data. Differentially private (DP) synthetic data offers a promising alternative with formal privacy guarantees, but achieving strong utility remains challenging for clinical note generation due to domain specificity and long-form text complexity. We present Term2Note, a method for synthesising full-length clinical notes under DP constraints. By structurally separating content and form, Term2Note generates section-wise note content conditioned on medical terms, with terms and notes privatised under separate DP constraints, and applies a DP quality maximiser to improve outputs. Experiments demonstrate that Term2Note produces synthetic notes with statistical properties closely aligned with real clinical notes, and that downstream models trained on these notes achieve performance comparable to those trained on real clinical data. Compared to existing DP text generation baselines, Term2Note substantially improves both fidelity and utility, without relying on label distribution assumptions, highlighting its effectiveness as a practical privacy-preserving alternative to real clinical notes.
Initial evaluations using various machine-learning algorithms on pre-and post-generalized datasets demonstrate the privacy framework’s effectiveness in mitigating privacy risks while preserving data usability.
Ze-Yang Zhu, Matthias N. Louws, Roland V. Bumbuc et al.· 0 citations
This work proposes a practical framework for assessing privacy risk in clinical foundation models and illustrates realistic leakage scenarios across deployment settings, map them to legal regimes, and outline complementary technical and legal mitigations.
Sana Tonekaboni, Lena Stempfle, Sasha Ronaghi et al.· 0 citations
This framework enables the generation of deidentified Japanese EHR narratives that preserve contextual structure for auditing while supporting structured entity extraction, thereby addressing the trade-off between privacy protection and reproducibility in real-world data research.
Nobuo Mochizuki, Atsushi Ikeda, Hideyuki Ohshima et al.· JMIR Medical Informatics· 0 citations
This work introduces and evaluates a privacy-preserving knowledge distillation framework for LLM-based clinical modeling, using multimorbidity scoring as a healthcare task, and establishes a trustworthy, privacy-compliant pathway for large-scale healthcare applications of LLMs.
R. Awasthi, Yi-He Yang, Meng-Xuan Li et al.· medRxiv· 0 citations
It is shown that Transparency, privacy, scalability, and fidelity are all linked in complex ways with the principles of medical ethics and it is shown that when privacy is privileged over other values, it conflicts with autonomy and beneficence.
Yael Friedman, A. Smajdor· Health Care Analysis· 0 citations
Verified Extraction is introduced, an auditing framework that distinguishes identifiers attributable to fine-tuning data from spurious or prior-driven outputs and quantifies recoverable leakage under explicit query budgets.
Florent Pollet, Tong Wang, Rahul Gupta et al.· 0 citations
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