anti-MUc1 nano-aptamers for triple-negative breast cancer imaging by single-photon emission computed tomography in inducted animals: initial considerations
The biodistribution assay in induced animal models with TNBC showed that although there was a high capture by intestine, the DDS developed had a high tumor uptake and with great in vivo imaging properties, corroborating the possibility of use of this DDS as an imaging drug for TNBC.
B7−H3 is widely expressed in multiple solid tumors but shows minimal expression in normal tissues, making it an ideal target for molecular imaging; however, its systematic investigation remains limited. In this study, we utilized the clinically investigated B7−H3-targeted antibody−drug conjugate (ADC) HS-20093 to dev...
Jia-Yu Sui, Jing-Jie Qin, Jessica C. Hsu et al.· Molecular Pharmaceutics· 0 citations
Purpose: TRA-1-60 (TRA) is an established cancer stemness marker implicated in tumor initiation, therapeutic resistance, and disease relapse. It is minimally expressed in normal differentiated tissues, making it an appealing biomarker for immunopositron emission tomography (immunoPET) imaging and radiopharmaceutical th...
Sajmina Khatun, Farzaneh Rezazadeh, A. Deck et al.· Research Square· 0 citations
Purpose TRA-1–60 (TRA) is an established cancer stemness marker implicated in tumor initiation, therapeutic resistance, and disease relapse. It is minimally expressed in normal differentiated tissues, making it an appealing biomarker for immunopositron emission tomography (immunoPET) imaging and radiopharmaceutical the...
Programmed death-ligand 1 (PD-L1) is a dynamic biomarker relevant to radiotherapy and immunotherapy, motivating the development of noninvasive approaches for longitudinal assessment. Here we report a PD-L1–targeted near-infrared II (NIR-II) fluorescent probe, PNF-ICG, generated by conjugating a cyclic PD-L1–binding p...
Zhan-Yuan Li, Kang Zhu, Ying Wu et al.· Chemical & Biomedical
Im...· 0 citations
Fluorescence imaging of breast cancer is often limited by high background signals from conventional “always-on” probes. The nucleolin-targeting AS1411 aptamer provides a promising recognition element for tumors with elevated nucleolin expression, including triple-negative breast cancer (TNBC). This study aimed to d...
Jun-Tao Tan, Zi-Xi Hu, Da Huang et al.· Frontiers in Bioengineering...· 0 citations
Triple-negative breast cancer (TNBC) continues to resist the therapeutic gains achieved in other breast cancer subtypes, and much of that resistance, it turns out, is less about the drugs themselves than about where they end up in the body. Passively targeted nanocarriers were meant to solve this, yet a substantial bod...
