Antipsychotic-like effects of TAAR1 agonists and D2 receptor blockers are mediated through distinct modulation of striatal neuronal dynamics.

Dopamine D2 receptor dependent and independent structural, intrinsic and synaptic adaptations in experimental parkinsonism.

D2R signaling is identified as a major determinant of iMSN structural and intrinsic physiological integrity and global loss of D2R function reproduces many of the adaptations induced by dopamine depletion, indicating that dopamine depletion drives distinct forms of plasticity through separable D2R dependent and indepen...

852. Preclinical models of non dopaminergic antipsychotics

Abstract Background Current antipsychotic treatments primarily rely on dopamine D2 receptor antagonism and show limited efficacy for negative and cognitive symptoms, as well as in treatment-resistant schizophrenia. Trace amine-associated receptor 1 (TAAR1) agonists represent a promising non-dopaminergic approach with a...

Hippocampal synaptic transmission and Ca2⁺ signaling are altered by the selective 5-HT2A receptor agonist, 25CN-NBOH.

Findings reveal separable mechanisms of action: 5-HT2A-independent, presynaptic facilitation, and 5-HT2A-dependent calcium signaling in mouse hippocampal CA1 pyramidal neurons.

403. Sustained administration of the full and partial agonists of trace amine associated receptor 1 (TAAR1) induces different effects on the excitability of central monoaminergic neurons

Abstract Background Trace amine associated receptor 1 (TAAR1) is a promising target for the next generation of the central nervous system (CNS) drugs. It has been previously shown that the full (RO5256390) and partial (RO5263397) agonists of TAAR1 had anti-addictive, pro-cognitive, and antipsychotic- and antidepressant...

Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning

It is shown that D2Rs can bypass second messenger systems to tune glutamatergic transmission through receptor-receptor interactions, providing a mechanism by which dopamine selectively gates specific glutamatergic inputs to control striatal plasticity and behavioral adaptation.

Striatal Dopamine D2 Receptors Contribute to N-Ethylpentylone-Induced Arousal in Mice