Jul 2026· ACS Applied Bio Materials· Vol 9, pp. 7102-7113· 0 citations· 44 references
Medicine
Abstract
Microbial biofilms are highly resistant to conventional antibiotics, leading to persistent infection and rapid food spoilage. In this study, pentabromophenol (PBP) loaded liposomes were synthesized as a dual-functional nanocarrier for antibiofilm activity and postharvest grape preservation. The optimized formulation 3 showed lipid vesicles, strong colloidal stability, and a high encapsulation efficiency of 94%. Encapsulation significantly improved the antibiofilm activity of PBP against Staphylococcus aureus, achieving 86.9% inhibition at 0.1 µg/mL, which is fivefold higher than that of free PBP. A lipid-mixing assay confirmed concentration-dependent membrane fusion that facilitated sustained PBP release and efficient biofilm inhibition. When applied as a coating, PBP liposomes reduced microbial growth by more than 80%, maintained grape firmness, and minimized weight loss during 7 days of storage. Biocompatibility assays using Raphanus sativus and Caenorhabditis elegans demonstrated no potential toxicity. Overall, PBP liposomes offer a safe and efficient platform for controlling S. aureus and extending grape shelf life.
Pathogenic biofilms and complex biological environments significantly limit the therapeutic efficacy of antimicrobial peptides such as Nisin Z due to rapid degradation and poor penetration. In this study, we developed a Nisin Z-loaded chitosan-pectin coated liposome (LCPN) as a lipid-polymer hybrid nanosystem to over...
Minh Quan Ho, Nam-Son Dinh-Ngoc, Quynh-Anh Vu-Yen et al.· ACS Applied Nano Materials· 0 citations
Polydopamine-functionalized sodium alginate nanoparticles (SA-PDAs) were fabricated through self-assembly of dopamine-modified sodium alginate with cetyltrimethylammonium bromide and Tween 80, followed by in situ oxidative polymerization. The nanoparticle served as an excellent carrier for the controlled release of ema...
Xiao-Qiu Wen, He-Lin Wang, Sheng-Qian Wu et al.· Journal of Agricultural and...· 0 citations
Flavonoids with halogen substituents represent a promising group of bioactive compounds, but their poor aqueous solubility and limited bioavailability restrict their therapeutic application. This study aimed to develop and evaluate a SPC/cholesterol/TPGS/DOTAP-modified cationic liposomal system for the delivery of 8-...
Anita Dudek, Aleksandra Pawlak, Paulina Strugała-Danak et al.· Scientific Reports· 0 citations
Surface modification is an effective strategy to combat microbial colonization by inhibiting growth or directly inactivating bacteria. In this study, polyurethane (PU)-based nanocomposites (NCs) incorporating saponite nanoparticles modified with poly(diallyldimethylammonium chloride) (PDDA) and functionalized with th...
Katarína Bilská, Marek Pribus, Juraj Bujdák et al.· ACS Omega· 0 citations
INTRODUCTION
The escalating incidence and severity of wheat crown rot poses a profound threat to global wheat yields and food security. Despite widespread fungicide application, the spatial mismatch between deposition sites and pathogen infection loci limits the precision and sufficiency of delivery, thereby reducing d...
Chengying Ding, Lingyan Liu, Xue-Jian Cheng et al.· Journal of Advanced Research· 0 citations
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