Sedative Efficacy and Dose Sparing Effect of Butorphanol-acepromazine-glycopyrrolate in Dogs Induced with Propofol or Thiopentone and Maintained on Isoflurane Anaesthesia

Abstract

Background: Premedication plays an important role in balanced anaesthesia by improving sedation, facilitating handling and reducing anaesthetic requirements. The present study evaluated the sedative efficacy and dose-sparing effect of butorphanol-acepromazine-glycopyrrolate premedication on propofol and thiopentone induction anaesthesia in dogs. Methods: Twenty-four client-owned dogs undergoing various surgical procedures were randomly divided into two groups. All dogs received butorphanol (0.2 mg/kg IM), acepromazine (0.02 mg/kg IV) and glycopyrrolate (0.01 mg/kg IM). Anaesthesia was induced with propofol in Group I and thiopentone sodium in Group II and maintained with isoflurane in oxygen in both the groups. Sedation quality, induction dose, induction characteristics and recovery parameters were evaluated. Result: Premedication produced good to excellent sedation in all dogs. Mean induction doses of propofol (2.89±0.21 mg/kg) and thiopentone sodium (8.16±0.71 mg/kg) were markedly lower than conventional doses. Propofol provided smoother induction and significantly faster recovery than thiopentone sodium.