QbD-Optimized CD44-Targeted Hyaluronic Acid Chitosan Nanoparticles in Dual pH-Responsive Capsules for Colon-Directed Oral Delivery of 5-Fluorouracil

Chitosan-Coated Eudragit® Nanocomposite Hesperetin Nanoparticles: A Dual Mucoadhesive and pH-Responsive Strategy for Colon-Targeted Drug Delivery

Development and Optimisation Using D-Optimal Design of Dual-Functionalized Hyaluronic Acid-Chitosan-Coated Mesoporous Silica Nanoparticles for Repurposed Propranolol Delivery in Breast Cancer: A Proof-of-Concept Study.

Drug repurposing combined with nanocarrier systems can accelerate cancer therapy development while reducing the time and cost of conventional drug discovery. We developed and optimised hyaluronic acid (HA)-chitosan (CH)-coated mesoporous silica nanoparticles (HA-CH-Prop-MSNPs) for delivery of the repurposed β-blocker p...

Linoleic acid-based pH-sensitive 5-ASA nanocubosome pellets for colon targeting in ulcerative colitis: in vitro and in vivo comparison with non-pH-sensitive and conventional formulations.

OBJECTIVE This study aimed to design and evaluate pH-sensitive pellets loaded with 5-aminosalicylic acid (5-ASA) for targeted colon delivery in ulcerative colitis (UC) therapy. SIGNIFICANCE The proposed formulation leverages glyceryl monooleate (GMO) and linoleic acid (LA) as liquid crystal precursors to achieve site...

Optimized Lamotrigine-Loaded Polymeric Nanoparticles for Enhanced Drug Delivery: A Box-Behnken Design Approach with Integrated In Vivo Evaluation

The clinical utility of lamotrigine in epilepsy is limited by poor aqueous solubility, variable oral absorption, short half-life, and P-glycoprotein-mediated efflux at the blood-brain barrier. This study aimed to develop an optimized chitosan-sodium alginate polymeric nanoparticle system for Lamotrigine with desire...

FORMULATION AND QBD-BASED OPTIMIZATION OF CHITOSAN-COATED NANOSTRUCTURED LIPID CARRIERS FOR ENHANCED DRUG DELIVERY OF AZILSARTAN MEDOXOMIL

Objective: Azilsartan medoxomil (AZM) is a Class II antihypertensive drug with poor aqueous solubility that limit its dissolution and oral performance. The aim of present investigation was to improve its dissolution properties by formulating chitosan-coated AZM NLCs (CH-NLCs) and optimizing using QbD approach. Methods:...

Electrospun PLA: Gelatin core-shell nanofibers for dual delivery of docetaxel and heparin with enhanced in vitro antiproliferative activity.

Overall, the developed PLA:Gel core-shell nanofibers represent a promising biomaterial-based platform for dual drug delivery of hydrophobic and hydrophilic agents, offering controlled release and promising in vitro antiproliferative activity.