TL;DR
It can be concluded that the combination of Poloxamer 407 and Syloid® 244FP has been proved effective in improving the solubility, dissolution, and antibacterial performance of azithromycin, and has established the potential of mesoporous carrier-based solid dispersions for enhancing the oral delivery of azithromycin.
Poloxamers are triblock copolymers commonly used in pharmaceutical formulation development to enhance the solubility of poorly water-soluble compounds. The present study investigated the efficiency of the hydrophilic carriers, poloxamer 188 (P188) and poloxamer 407 (P407), in preparing solid dispersions (SDs) of efavir...
The present investigation was undertaken to develop and evaluate orally disintegrating tablets (ODTs) of Aprepitant as a rapid and patient-friendly dosage form for the management of chemotherapy-induced nausea and vomiting. Preformulation studies involving drug identification, solubility assessment, melting point deter...
Background: Dolutegravir (DTG) is a potent HIV-1 integrase inhibitor with poor aqueous solubility, which can limit its dissolution and oral absorption. Objective: To develop and optimize dolutegravir solid dispersions using hydrophilic carriers for enhancement of solubility and dissolution. Methods: Solid dispersions w...
Overall, the developed transferosomal system demonstrated improved permeation, sustained release, and biocompatibility, suggesting its potential as a promising topical delivery.
Background: Ketoconazole (KTZ) is a poorly water-soluble antifungal drug for which dissolution enhancement may improve oral formulation performance. Natural polysaccharides are attractive carriers because of their availability and biocompatibility, while chemical functionalization can modify their physicochemical behav...
Voriconazole is a broad-spectrum triazole antifungal with limited aqueous solubility. The present study was designed to formulate and evaluate a voriconazole-loaded topical gel using Carbopol 971P for localized antifungal delivery. Five formulations (F1-F5) were prepared with increasing concentrations of Carbopol 971P...
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