Einfluss des Darmmikrobioms auf Gesundheit und Alterung

Abstract

During aging, the gut microbiome undergoes profound compositional and functional changes that may compromise host health. Using metabolic modeling and mouse studies, we showed that aging is associated with reduced microbial cooperation, lower production of beneficial metabolites, accumulation of pro-inflammatory compounds, impaired barrier function and systemic inflammation. Targeted modulation of microbial metabolism may therefore support healthier aging.