Open access
Oral Butyrate Reduces Progression of Kidney Damage in an L‐NAME‐Induced Diabetic Kidney Disease Mouse Model
M. Nicese
A. Koudijs
Reshma A. Lalai
Cristina Avramut
Rico J. E. Derks
E. Sánchez-López
M. Giera
A. Pronk
A. Kovynev
S. Kooijman
P. Rensen
Roel Bijkerk
B. M. van den Berg
J. Rotmans
Aug 2026 · Diabetes, obesity and metabolism · Vol 28, pp. 10278 - 10291 · 0 citations
· 73 references
Medicine
Abstract
Diabetic kidney disease (DKD) is one of the main causes of kidney failure worldwide. Interestingly, patients affected by DKD are characterised by a low abundance of gut bacteria producing short fatty acids including butyrate, which is suggested to play a role in the decline of renal function. Consequently, we aimed to test the effects of oral butyrate supplementation on kidney health in mice affected by DKD.