NaHS inhibits cell proliferation by enhancing oxidative stress and apoptosis in HCT116 cells

Boric Acid Induces Oxidative Stress-Associated Cytotoxicity and Modulates Wnt Signaling in MALME-3M Cells.

Estragole Induces Apoptosis in A549 Lung Cancer Cells via ROS-mediated Oxidative Stress and Modulation of Caspase Activation and Bax/Bcl-2 Pathway

Lung cancer remains a major cause of death globally, responsible for a significant portion of all cancer-related deaths despite advancements in therapeutic modalities. Consequently, there is a great demand for new treatment strategies that can improve anti-cancer efficiency while minimizing toxicity in vivo ....

Comparative Effects of Metformin, Boric Acid, and Lithium Chloride on Oxidative Stress-Mediated Cytotoxicity in HepG2 Hepatocarcinoma Cells.

Rosmarinic Acid Enhances Doxorubicin Activity in MDA-MB-231 Cells: Associations with Intracellular Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Background/Objectives: Rosmarinic acid (RA) is a naturally occurring polyphenolic compound with promising anticancer activity; however, its potential to enhance the therapeutic efficacy of doxorubicin (DOX) against triple-negative breast cancer (TNBC) has not been comprehensively characterised. This study investigated...

Saikosaponin A Induces Apoptosis in HCT116 Colorectal Cancer Cells via ROS-Mediated ER Stress and p38/JNK MAPK Pathway Activation: in Vitro and in Vivo Evidence

Colorectal cancer (CRC) is the third most prevalent cancer globally, with limited effective treatment options and significant chemotherapy resistance. Saikosaponin A (SSA), a triterpenoid saponin from Radix Bupleuri, exhibits anti-inflammatory and antitumor properties, but its mechanism of action in CRC remains und...

Oxidative stress-associated mitochondrial depolarization correlates with apoptotic response in karanjin-treated cancer cells

Karanjin is a furanoflavanoid that demonstrates selective cytotoxic effects toward various cancer cells; however, its underlying mechanism has yet to be thoroughly investigated. This study aimed to elucidate the molecular mechanisms underlying karanjin-induced cytotoxicity across cancer (HeLa, MCF-7, A549, and HCT116)...