Protective effects of thymoquinone against hexavalent chromium-ınduced nephrotoxicity: a multiparametric evaluation of oxidative stress, ınflammation, ferroptosis- and apoptosis-related markers

Open access Aug 2026

Protective effects of 1,8-cineole against potassium dichromate-induced nephrotoxicity in rats: Evaluation of oxidative stress, inflammatory, and apoptotic pathways

Aim: Potassium dichromate is a heavy metal associated with nephrotoxicity in people and animals, resulting in oxidative stress, inflammation, and apoptosis in tissues. 1,8-cineole is a monoterpene with antioxidant, anti-inflammatory, and anti-apoptotic properties. This study aimed to investigate the potential protectiv...

Tansu Kuşat, Feyza Başak, Eyüp Altınöz et al. · Medical Journal of Western B... · 0 citations

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Open access Sep 2026

Comparative Protective Effects of Khaya grandifoliola CDC and Zingiber officinale against Cisplatin Induced Hepatic and Renal Toxicity through Antioxidant Mechanisms

Cisplatin is a widely used platinum-based chemotherapeutic agent whose clinical efficacy is limited by severe hepatotoxicity and nephrotoxicity mainly mediated through oxidative stress and inflammation. The present study evaluated the protective effects of hydroethanolic extracts of Khaya grandifoliola (KG) bark and aq...

Danielle Yaba Ambassa, Charnelle Fokoua Bakam, B. Enang et al. · Exon · 0 citations

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2026

Asiatic Acid Ameliorates Chlorpyrifos-Induced Toxicity in Rats: Biochemical and Histopathological Insights

This study provides the first demonstration that asiatic acid exerts robust systemic antioxidative, hepatoprotective, and neuroprotective effects against CPF-induced toxicity, highlighting AA’s therapeutic potential for mitigating organophosphate pesticide poisoning.

Özge Darakcı Saltık, H. Balcı, Figen Güzelgül et al. · Yüksek İhtisas Üniversitesi... · 0 citations

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Aug 2026

Hepatoprotective effects of carvacrol nano-phytosomes against lead toxicity: Restoration of tissue architecture via NF-κB/NLRP3 suppression and antioxidant enhancement.

The objective of the current study was to assess the hepatoprotective properties of nano-phytosomes (CRV-PNPs) loaded with carvacrol (CRV) in response to lead (Pb)- triggered liver injury. Male Wistar rats were assigned to six groups: Control, CRV, CRV-PNPs, Pb, Pb/CRV, and Pb/CRV-PNPs. Pb intoxication led to considera...

Eman E. Elwakeel, Ahmed Abdeen, A. Elzeer et al. · Tissue & Cell · 0 citations

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2026

Hesperidin mitigates DEHP-induced nephrotoxicity through anti-oxidant, anti-apoptotic, and anti-inflammatory pathway modulation: Evidence from Nrf2/HO-1/Keap-1, Bax/Bcl-2/caspase-3, and TLR4/NF-κB axis activation

The protective mechanism involves anti-oxidant enhancement and inhibition of oxidative stress-induced inflammation and apoptosis, supporting the therapeutic potential of HSP in managing phthalate-related renal injury.

Tuba Karaarslan, B. Yıldırım, F. Yildirim et al. · Iranian Journal of Basic Med... · 0 citations

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Open access 2026

Protective effects of Rosmarinus officinalis against methotrexate-induced hepatorenal toxicity in Wistar rats: Biochemical, histopathological, and immunohistochemical evaluation

Rosmarinus officinalis extract may exert protective effects against MTX-induced hepatorenal injury through antioxidant and anti-inflammatory mechanisms, however, further studies are required to confirm these effects and validate their therapeutic potential.

Lana Muhammed, Nadia Salih · Open Veterinary Journal · 0 citations

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