Evaluation of the Antioxidative and Hepatoprotective Activity of Ulva lactuca in a CCl4-Induced Liver Injury Model

Antioxidant and anti-inflammatory effects of polyphenol-rich Illicium verum extract on lipopolysaccharide-induced liver injury in rats

Pretreatment with PEIV significantly mitigated effects of LPS-induced liver injury by regulating biochemical parameters, reducing oxidative stress and inflammation, and preserving liver architecture, suggesting its potential as a natural therapeutic agent for liver diseases.

Guazuma ulmifolia butanol extract protects against cadmium-induced hepatotoxicity via HO-1/Sirt-1 activation, miRNA–lncRNA modulation, and metabolic reprogramming

Gul-BuOH affords dose-dependent protection against Cd-induced liver injury by modulating oxidative stress, inflammation, metal detoxification, and metabolic pathways, supporting the traditional use of G. ulmifolia and its potential as a multi-target hepatoprotective agent.

HPLC-PDA-MS/MS Profiling, In Vitro and In Vivo Evaluation of Melilotus indicus Stem Extract: Insights Into its Antioxidant and Hepatoprotective Mechanisms for Potential Therapeutic Applications

Evaluation of the Hepatoprotective Efficacy of Mimusops elengi L. Fruits in a Carbon Tetrachloride-induced Rat Model

Liver diseases are a major global health burden, and oxidative stress plays a key role in the development of hepatocellular injury. Mimusops elengi L. fruits contain bioactive phytochemicals with reported antioxidant properties. This study aimed to evaluate the hepatoprotective activity of aqueous Mimusops elengi fruit extract against carbon tetrachloride (CCl4)-induced liver injury in Wistar rats. Male Wistar rats were randomly allocated into five groups (n = 5). Hepatic injury was induced using CCl4 (1 mL/kg, i.p.) for 15 days. Animals received Mimusops elengi fruit extract (200 and 400 mg/kg, orally) or silymarin (25 mg/kg). Serum ALT, AST, and catalase activity were evaluated, followed by histopathological examination of liver tissues. CCl4 administration significantly increased serum ALT and AST levels while reducing catalase activity, indicating severe hepatic injury. Treatment with Mimusops elengi fruit extract significantly reduced liver enzyme levels and improved antioxidant status in a dose-dependent manner. Histopathological examination demonstrated preservation of hepatic architecture, reduced necrosis and decreased inflammatory changes, particularly at 400 mg/kg. The hepatopr tective activity observed may be attributed to the antioxidant and membrane- stabilizing properties of flavonoids, tannins, and saponins present in Mimusops elengi fruits. The biochemical and histopathological findings collectively support the traditional medicinal use of this plant for liver protection and suggest its potential as a natural hepatoprotective agent. Mimusops elengi fruit extract exhibits significant hepatoprotective effects against CCl4-induced liver injury, likely mediated through antioxidant mechanisms. These findings support its potential as a natural therapeutic agent, although further studies are required to elucidate its active constituents and molecular pathways.

EVALUATION OF THE HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITIES OF HYDROALCOHOLIC EXTRACT OF IMPATIENS BALSAMINA LINN. LEAVES AGAINST DICLOFENAC-INDUCED HEPATOTOXICITY IN RATS

Findings suggest that the hepatoprotective effect of HAEIB may be attributed to its antioxidant phytoconstituents and support its potential use as a natural hepatoprotective agent.

Phytochemical Profiling and Preliminary Hepatoprotective Screening of Different Solvent Fractions of Elaeagnus parvifolia Fruit Extract Against Carbon Tetrachloride (CCl₄)–Induced Liver Injury in Mice

Results confirm potent hepatoprotective effects linked to antioxidant and phenolic constituents, supporting E. parvifolia as a promising natural liver protectant against carbon tetrachloride–induced hepatotoxicity in mice.