Review
Open access
Ketamine and esketamine for postoperative analgesia in gynaecological surgery
S. Marchesi
Jaquette Liljencrantz
A. Balintescu
Ioannis Soumpasis
Emma Sinervo
Said Makari
Peter Bentzer
M. F. Bjurström
Medicine
Abstract
Objectives This is a protocol for a Cochrane review (intervention). The objectives are as follows: The primary objective of this review is to evaluate the benefits and harms of a subanaesthetic dosage of ketamine/esketamine as an adjunct to perioperative analgesia versus standard analgesia or placebo for reducing postoperative pain in participants undergoing gynaecological surgical procedures. A secondary objective is to assess whether these outcomes differ by type of surgery, background condition, type of drug used (ketamine or esketamine), dosage, and presence of preoperative chronic pain or preoperative long‐term or recurrent opioid use.