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Remifentanil attenuated LPS-induced hepatic injury, and this effect was found to be associated with modulation of oxidative stress responses, inflammatory alterations, and necroptosis-related gene expression.
Purpose: To investigate the effect of taxifolin in sepsis-induced renal injury.Methods: A total of 24 adult male Swiss albino mice were randomly and equally assigned to 4 groups (n = 6). Group 1 was the control (exposed to abdominal laparotomy without cecal ligation and puncture (CLP) procedure), group 2 underwent CLP...
Thioacetamide (TAA) induces renal injury via oxidative stress and inflammation. Remogliflozin (Remo), an SGLT2 inhibitor, was evaluated for potential renoprotection. Twenty-four male Wistar rats were assigned to control, TAA (100 mg/kg IP twice weekly), TAA + Remo 25 mg/kg, or TAA + Remo 50 mg/kg (oral daily). Outcomes...
Cellular stress is implicated in the progression of lipopolysaccharide (LPS)‐evoked acute lung injury (ALI). The goal of this study was to evaluate the effect of oral supplementation with rosiglitazone (RSG), which is an agonist of peroxisome proliferator‐activated receptor (PPAR)‐γ, on pulmonary inflammatory response,...
BACKGROUND Sepsis-induced acute lung injury (ALI) is a critical illness with a high mortality rate. Madecassic acid (MA), a pentacyclic triterpenoid extracted from Centella asiatica, exhibits multiple biological activities, but its role in sepsis-associated ALI remains poorly elucidated. OBJECTIVES The aim of this st...
Collectively, DAPA exhibits hepatoprotective and neuroprotective effects against TAA-induced HE accompanied by modulation in oxidative-, inflammatory-, and apoptotic-related protein expression, highlighting its therapeutic potential in hepatic encephalopathy.
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