Future progress of dendrimers will be accelerated by more simplified and easily scalable synthetic processes, enhanced targeting to specific tissues and cells, as well as artificial intelligence-assisted design and optimization to posture dendrimers as a next-generation platform for nucleic acid delivery and precision medicine.
This article provides a comprehensive overview of the evolving landscape of nucleic acid-based therapeutics and aims to inform clinicians, researchers, and pharmaceutical scientists about their current applications and future potential in modern healthcare.
Satyaraj Ombase, Shanmugarathanam Alagarsamy, R. Prasad et al.· Adolescência e Saúde· 0 citations
This review examines how molecular weight, polymer composition, cationic group chemistry and density, pKa, and polymer topology influence complexation efficiency with nucleic acid, polymer to nucleic acid ratio (N/P), polyplex stability, cellular uptake, endosomal escape, cytotoxicity, and transfection efficiency.
Joachim Emeka Arikibe, Anna Maria Mazzetta, Lisa Casagrande et al.· Open Research Europe· 0 citations
This review summarizes the remarkable potential of Framework Nucleic Acids (FNAs) as an intelligent nanoplatform for tumor diagnosis and therapy and discusses the major challenges for clinical translation.
Mengting Liu, Tiantian Wu, Qifeng Zhang et al.· Current drug metabolism· 0 citations
Various functionalized nanocarriers for gene delivery including silica-based nanoparticles, gold NPs, magnetic NPs, graphene-based materials, carbon nanotubes, polycationic systems, and lipidic nanostructures are summarized.
Houra Nekounam, Ali KarbalaeiMahdi, Faranak Mohammadi et al.· Nanotechnology· 0 citations
The importance of formulation optimization in improving nucleic acid delivery is highlighted and practical insights for enhancing peptide- and lipid-based therapeutic platforms are provided.
D. Daniele, Z. Hein, O. Saher et al.· International Journal of Pha...· 0 citations
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