A Review on Structural Insights into NLRP3 and NEK7: Domain Architecture, Subcellular Localization, and Their Interaction in Inflammasome Assembly and Signaling
Jan 2026· Molecular Neurobiology· Vol 63· 0 citations· 117 references
Medicine
TL;DR
The structural domains and subcellular localizations of NLRP3 and NEK7 are examined, and how their interaction promotes inflammasome assembly is highlighted, to address key unanswered questions that may guide future research into therapeutic modulation of these essential protein–protein interactions.
Inflammasomes ignite innate immune defense in response to infectious pathogens and noninfectious dangers, primarily through sensors composed of nucleotide-binding domain (NBD), leucine-rich repeat (LRR)-containing (NLR) family proteins. NLRP6 is an inflammasome sensor that plays critical roles in regulating intestinal...
Zhen Cui, Qi Sheng, Minsoo Son et al.· Nature Structural & Molecula...· 0 citations
A critical role is uncovered for intrinsically disordered regions (IDRs) in activating NLRP1, NLRP3, and NLRP14 inflammasomes, suggesting that targeting the dynamics of phase transitions could open novel therapeutic avenues for treating inflammatory and autoimmune diseases.
Teresa Nava-Ramírez, C. Cuevas-Velazquez, Alejandra A. Covarrubias et al.· Frontiers in Immunology· 0 citations
Deletion of MEX3B inhibited caspase-4 and gasdermin D activation, pyroptosis, and secretion of inflammasome-dependent inflammatory cytokines in human cell lines and murine primary macrophages and suggested that MEX3B is a pan-inflammasome regulator targeting inflammatory caspases.
Peng-Hua Wang, Jason G. Cahoon, Duo-Meng Yang et al.· Journal of Immunology· 0 citations
Treatment application of Pep19‐2.5 via the nasal aerosol route reduces IL‐1β levels, eosinophil infiltration in bronchoalveolar lavage and significantly improved lung function in an in vivo HDM‐mouse model of allergic airway inflammation.
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin et al.· Advancement of science· 0 citations
This study signifies the mechanisms underlying circadian regulation of the P2X7–NLRP3 axis, its tissue-specific roles in obesity, and available preclinical and clinical evidence, and further review innovative therapeutics like inflammatory inhibiting targets including inflammasome inhibitors, P2X7 antagonists and chron...
